Mehr news agency, without quoting a source, reported that two workers were killed in the explosion.
The website of state television said the explosion took place in the Mazdavand region near Mashhad when a mechanical shovel struck the pipeline.
It quoted Alireza Gharibi, head of Iran’s Gas Engineering and Development Company, as saying that the blast also left 16 others injured.
“The incident occurred where the existing pipeline crosses with one under construction,” Gharibi said.
The pipeline carries gas from the Sarakhs refinery to the holy city of Mashhad, the website said.