Americas actions have taken distrust in the region to its peak, Ali Larijani told reporters on the sidelines of a conference in Tehran on Irans nuclear activities.
He said that the U.S. was responsible for the expansion of terrorism in the region.
Larijani said, America must know that if it confronts us it will lose all its prestige in the world.
He added that a Zionist lobby had misguided Washington over how to deal with the issue of the Middle East.
He mocked attempts by U.S. Secretary of State Condoleezza Rice and British Prime Minister Tony Blair to help the establishment of the new Iraqi government, stating that they were unable to successfully carry out such a task.